PIX No Route error

It would be helpful if you could post your configuration

Have you tried a clear xlate command? I always forget to use that one when I make changes.

I had a similar problem with VPNs.. But mine was random. I would not be able to talk to one host out of 30 on (vlan 3) through the vpn.

I got %PIX-6-110001 no route.......

I found a nat rule natting my private vlan (or vlan 3) to "Same address". (Sorry I used the PDM) I think the line was:

nat (private) 0 access-list private_outbound_nat0_acl

I deleted that, and all my troubles went away.
I then added another rule to nat vlan 3 to the Outside interface IP.. and things were still working well.

Cool avatar! I have that expression too when my network is playing up...

I turned off "ip verify reverse-path interface" on the interface the packets were generating the "no route" message from.